Organ-on-a-Chips have emerged as a promising new technology in the field of human biology, offering a more authentic representation of human responses compared to traditional 2D cell culture. For decades, scientists have used conventional 2D cell culture to study human biology and make significant advancements in the field. However, it has become increasingly clear that the artificial nature of 2D cell culture, which includes the use of cancerous cell lines, static microenvironments, and limited cellular complexity, restricts its ability to accurately model human diseases and predict human reactions to drug candidates.
To address these limitations, researchers have developed Organ-Chips as an innovative cell culture technology that offers a more human-relevant platform for disease research and drug discovery and development. These advanced in vitro models replicate the microenvironment that cells experience within the human body, providing a more authentic representation of human responses compared to traditional 2D cell culture.
Recently, Luke Dimasi, Senior Director of Product Management at Emulate led a webinar on Organ-on-a-Chip technology. The webinar explores the advantages of Organ-Chips over 2D cell culture and offers data-driven examples demonstrating their enhanced physiological relevance. According to Dimasi, “Organ-Chips offer a unique opportunity to model complex biological systems with high precision and accuracy.” He adds “These models can help researchers identify potential drug targets or predict how drugs will interact with different tissues within the body.”