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In the wake of a global pandemic caused by a coronavirus four years ago, scientists have developed a new vaccine technology that provides protection against a broad spectrum of coronaviruses in mice. This innovative approach, known as “proactive vaccinology,” involves creating a vaccine before the pathogen causing the disease emerges. The vaccine trains the immune system to recognize specific regions of eight different coronaviruses, including those currently circulating and those that may jump to humans in the future.
Researchers from the University of Cambridge, the University of Oxford, and Caltech collaborated on this project and published their findings in the journal Nature Nanotechnology. The new “Quartet Nanocage” vaccine is based on a nanoparticle structure that binds viral antigens, training the immune system to target shared regions of coronaviruses. This design streamlines the vaccine development process and may facilitate its quicker transition to clinical trials. Furthermore, the underlying technology has potential applications in the development of vaccines against other health problems.
In comparison to previous research on broadly protective vaccines against coronaviruses, this new vaccine offers a more straightforward design and better efficiency. While an Oxford and Caltech group’s vaccine is set to enter clinical trials in early 2025, its complexity may pose challenges for large-scale production. Overall, proactive vaccinology shows promise in preparing for future outbreaks and potentially preventing unknown coronaviruses from causing pandemics.
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