Dr. Nguyen Thi Mong Diep and her team at Quy Nhon University have successfully developed recombinant eCG and hFSH hormones, which are expected to revolutionize assisted reproductive techniques by providing a more effective and accessible solution. These two new gonadotropin hormones were developed as part of the research conducted by the team, with the goal of supporting reproduction for both humans and animals.
In November 2020, the research group received funding from Vingroup Innovation Fund (VINIF) for the project “Production of single-chain gonadotropins for fertility treatment.” By April 2024, they successfully launched two hormones, eCG and hFSH, which have been shown to be biologically effective and require only a single injection for the entire treatment process. The team completed the production process, including design, plasmid amplification, expression on cells, purification, biological activity analysis in the laboratory, and testing on mammalian models.
Natural gonadotropin hormones have been used for a long time in treating infertility in humans and animals. However, challenges such as hygiene and ethical issues associated with their production and supply make them unsustainable. The research conducted by Dr. Nguyen Thi Mong Diep’s team aims to address these challenges by developing recombinant gonadotropin hormones as a viable alternative. These hormones offer a more sustainable and cost-effective solution for infertility treatment in humans and reproduction control in animals.
The development of recombinant single-chain hormones has shown promising results in improving fertility for both humans and animals. With high commercialization potential, this groundbreaking research can contribute to advancing Vietnam’s biotechnology sector while expanding opportunities for infertile couples to have children. According to Dr. Huynh Gia Bao, an expert in IVF techniques who collaborates with Dr. Nguyen Thi Mong Diep’s team on this project, it has the potential to help improve accessibility and reduce treatment costs for Vietnamese patients especially those in remote areas.
Dr. Nguyen Thi Mong Diep is recognized internationally as an associate professor who meets standards in France in 2024 and ranks among the top 3 candidates for specialized positions in Physiology, Biochemistry