• Sat. Apr 1st, 2023

Neuro News Roundup: Planet Sleep Day 2023


Mar 17, 2023

In existing months, the NeurologyLive® group has been covering the news on the newest updates in the clinical care of people with neuromuscular issues, a lot of sclerosis, movement issues, sleep issues, and a lot far more. For our coverage of sleep issues, our group has spoken with a quantity of specialists and highlighted quite a few clinical findings relevant for the populations of sufferers with issues such as narcolepsy, insomnia, cataplexy, and a number of other men and women.

For Planet Sleep Day—celebrated on March 17, 2023—the group has culminated some of the biggest pieces of news to present updates on new developments in the literature of sleep medicine to spread awareness on the prevention and remedy of sleep issues.

Click appropriate right here for a lot far more coverage of the newest news in sleep issues from NeurologyLive®.

Most existing Literature

Clinical and Neuropsychological Data on Narcolepsy Shows No Distinction in Comparison of International Networks

A not also lengthy ago published study (NCT05375890) in the Journal of Clinical Sleep Medicine showed nonsignificant variations in clinical and neuropsychological info in the Russian Narcolepsy Network (RN-NN) relative to that previously reported in the European Narcolepsy Network (EU-NN).1 The findings showed a lot far more intense and higher percentages of sufferers who sensible practical experience cataplexy in Russia, suggesting a low awareness of narcolepsy.

Comparing info with the EU-NN,two the RN-NN had fewer sufferers with excessive daytime sleepiness (EDS) as a initially symptom (25.six% vs 43.eight% P = .0014), whereas the percentage of every EDS and cataplexy as a initially symptom was virtually twice as larger as in the EU-NN info (67.4% vs 48.eight P = .0013). Notably, the prevalence of intense cataplexy situations was higher in the RN-NN than in the EU-NN info (93.eight% [n = 80] vs 62.six% [n = 829] in EU-NN P = .001).

Sleep paralysis (59.1%, n = 88) and hallucinations (82.%, n = 89 P = .0017) had been present in the RN-NN a lot far more normally than in the European cohort (52.six% [n = 257] and 63.1% [n = 370], respectively). Data with polysomnography and imply sleep latency test (MSLT) in RN-NN are comparable, even although observed MSLT scores (4.9 [±2.9] minutes [n = 52] vs 3.9 ± 3. minutes [n = 927] P = .0193) had been as higher in the Russian cohort.

Narcolepsy Causes Substantial Influence on Social Connection Effectively becoming in Adolescents, Study Shows

In an exploratory study not also lengthy ago published in the Journal of Clinical Sleep Medicine, findings revealed an overarching theme that adolescents and their parents sensible practical experience difficulty in attempting to balance narcolepsy symptom management with meaningful social engagement.3 In the study, symptoms of daytime fatigue and cataplexy had been the most considerable and normally discussed amongst adolescents and their parents as possessing an impact on social relationships.

Notably, adolescents reported feeling frustrated by their sleep disorder impacting their social lives such as constantly needing to approach ahead with their sleep schedule. Additionally, every adolescents and their parents expressed the will have to have for overall health-connected providers to higher comprehend their altering priorities, validate social limitations, and present a lot far more information about the social implications of scenario and remedy.

Adolescents involving the ages of 12 and 17 years old with narcolepsy and their parents completed a semistructured interview individually involving July 2021 and December 2021. Participants had been integrated if they had a confirmed diagnosis of narcolepsy kind 1 (n = 12 85.7%) or kind two (n = two 14.3%) producing use of polysomnography/MSLT or other testing and had been fluent in English. Data records had been extracted, mostly primarily based on their narcolepsy medication approach and Epworth Sleepiness Scale (ESS) score 3 months prior to the interview date, from Boston Children’s Hospital. Of note, 3 sufferers had a overall health-connected record from outdoors the hospital. Interview transcripts had been analyzed producing use of a multistage thematic evaluation.

Titration Widespread in Solriamfetol, Leads to Improvements in Daytime Sleepiness

Solriamfetol (Sunosi Axsome Therapeutics), an FDA-authorized medication for EDS, is ordinarily initiated at 75 mg/day, with titration common, according to the SURWEY study assessing accurate-globe medical professional strategies.4 Following initiation, sufferers seasoned improvements in ESS scores, and most sufferers perceived improvement in their EDS status.

The most common starting doses all round had been 75 mg/day (69%) or 150 mg/day (20%), with most of the remaining sufferers initiated at 37.5 mg. Virtually half (43%) of sufferers had their remedy titrated, with 90% finishing titration as prescribed. Titration was most normally completed inside 7 days (57%). For sufferers who changed remedy, switching to solriamfetol was managed producing use of an abrupt approach for 88% of sufferers, an overlapping (tapered) approach for 9% of sufferers, and an unknown approach for two% of sufferers.

Retrospective chart evaluations from 70 German adults with EDS and narcolepsy had been collected by investigators, with sufferers classified as either changeover (n = 43 61%), add-on (n = 19 27%), or new-to-therapy (n = eight 11%) subgroups, mostly primarily based on existing EDS remedy. The imply age of the cohort was 36.9 (±13.9) years and imply physique mass index was 26.7 (SD, 5.two) kg/m. A lot far more than half (57%) had cataplexy, and most (84%) had been treated in sleep centers.

Adjustments in Sleep Architecture, Comorbidities Observed in Extended-Term Therapy With Sodium Oxybate

Findings from a compact-scale, longitudinal study assessing sufferers with narcolepsy with cataplexy (NT1) showed that following 3 years of remedy with low to medium doses of sodium oxybate, there had been considerable variations in sleep structure and an increase in comorbidities that led to drug withdrawal.5

To the study authors understanding, this was the longest recorded trial evaluating the effect of sodium oxybate on sleep architecture and comorbidity with video-polysomnography. The trial featured 23 adults with NT1 who had been treated with an initial nocturnal dose of 4.5 g of sodium oxybate, with sleep parameters compared following six months (FU-1), 1 year (FU-two), and 3 years (FU-3) of uninterrupted remedy.

Findings on video polysomnography showed an increase in stage N3 in the initially sleep cycle and a REM-onset in 90% of sufferers following the administration of the initially dose. When comparing the time spent in the diverse sleep stages involving FU-1 and FU-two, sufferers elevated the time spent in stage N2 (z = –2.17 P = .03). At FU-3, there was a considerable elevated observed in the time spent in stage N1 (z = –2.09 P = .03). Also the time spent in stages N1 and N2 had been drastically longer in the newest stick to-up than at FU-1 (z = –2.36 P = .001).

Although Frequently Employed, Complementary and Alternative Medicine Ineffective to Treat Narcolepsy

Findings from a existing survey of 254 German sufferers with narcolepsy showed that biologically mostly primarily based therapies had been the most frequently produced use of in complementary and alternative medicine (CAM) subgroups (76%) nonetheless, their impact is restricted. Although on these drugs, sufferers nonetheless felt the will have to have to boost their symptoms, sleepiness, and psychological nicely having.six

Amongst 33% of CAM prospects (n = 84), vitamins/trace elements (54%), homoeopathy (48%) and meditation (39%) had been produced use of most frequently. Fifty-four prospects (64%) described CAM as helpful. CAM prospects a lot far more frequently reported side effects from prior medication (P = .001). Notably, CAM prospects reported a lot far more frequently not complying with pharmacological remedy than nonCAM prospects (21% vs. eight% P = .024).

When a week or a lot far more, 75% of CAM prospects utilized CAM and whereas only 23% of prospects did only when a month or a lot far more. Twenty-three % of sufferers who did not take any common pharmacological remedy prior (n = 38) reported current CAM use. Twenty-seven % of sufferers produced use of every common medicine and CAM at the identical time (n =69). Amongst these who reported earlier or present CAM use, 73% reported possessing automatic behavior (n = 61 vs. n = 97 nonCAM prospects), 68% reported hypnagogic/hypnopompic hallucinations (n = 57 vs. n = 91 nonCAM prospects), and 70% reported nightmares (n = 59 vs. n = 97 nonCAM prospects).

1. Kuts A, Poluektov M, Zakharov A, et al. Clinical and neurophysiological traits of 89 sufferers with narcolepsy and cataplexy from the Russian Narcolepsy Network. J Clin Sleep Med. 202319(two):355-359. doi:ten.5664/jcsm.10340
two. Luca G, Haba-Rubio J, Dauvilliers Y, et al. Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study. J Sleep Res. 201322(5):482-495. doi:ten.1111/jsr.12044
3. Zhou ES, Revette A, Heckler GK, Worhach J, Maski K, Owens JA. Constructing a deeper understanding of social partnership all round overall health in adolescents with narcolepsy disorder. J Clin Sleep Med. 202319(3):491-498. doi:ten.5664/jcsm.10372
4. Winter Y, Mayer G, Kotterba S. Solriamfetol accurate globe sensible practical experience study (SURWEY): initiation, titration, safety, effectiveness, and sensible practical experience all through stick to-up for sufferers with narcolepsy from Germany. Sleep Med. 2023103:138-143. doi:ten.1016/j.sleep.2023.01.022.
5. Adrados MRP, Bellon JM, Triguero LL, Lopez-Esteban P, Medrano-Martinez P. Extended-term stick to-up on the effects of sodium oxybae on daytime sleepiness and sleep architecture in sufferers with narcolepsy kind 1. Rev Neurol. Published January 16, 2023. doi:ten.33588/rn.7602.2022315
six. Finger BM, Triller A, Bourke AM, et al. Complementary and alternative medicine use in narcolepsy. Sleep Med. 2023103:a single hundred-105. doi:ten.1016/j.sleep.2023.01.013

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