• Sat. Apr 20th, 2024

Cartherics and TiCARos team up for cancer therapy breakthrough with CAR-NK therapeutic products

BySamantha Jones

Apr 3, 2024
Cartherics and TiCARos collaborate to lead advancement of CLIP-CAR technology

Cartherics and TiCARos have announced a collaboration to develop CAR-NK therapeutic products for cancer treatment. TiCARos will provide CLIP-CAR constructs that will be incorporated into Cartherics’ allogeneic NK cells for in vitro and in vivo assessments of their function.

TiCARos specializes in developing CAR-T cell products for treating solid and blood cancers using its unique CLIP-CAR approach. This method modifies the CAR structure to stabilize the immune synapse between immune cells and target tumor cells, resulting in improved efficacy in models.

Cartherics’ CEO, Professor Alan Trounson, believes that combining TiCARos’ CLIP-CAR technology with Cartherics’ allogeneic NK cell platform has the potential to enhance the effectiveness of cancer therapies. By collaborating with innovative companies like TiCARos, Cartherics aims to build a leading portfolio of therapeutic products for cancer treatment. The collaboration between the two companies aims to develop a CAR-NK product targeting tissue factor for triple negative breast cancer and other challenging cancers.

Each company has nominated a specific tumor antigen to target with the CARs, with Cartherics focusing on tissue factor (TF) and TiCARos targeting CD19. The collaboration between the two companies aims to accelerate pipeline programs and expand the use of TiCARos’ technology beyond autologous cell therapies. If the research collaboration yields positive results, Cartherics and TiCARos will negotiate a development and commercialization agreement for their CAR-NK therapeutic approach.

By Samantha Jones

As a content writer at newsnnk.com, I weave words into captivating stories that inform and engage our readers. With a passion for storytelling and an eye for detail, I strive to deliver high-quality and engaging content that resonates with our audience. From breaking news to thought-provoking features, I am dedicated to providing informative and compelling articles that keep our readers informed and entertained. Join me on this journey as we explore the world through the power of words.

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